SYNTHESIS OF AZO-SULFA DRUGS BASED ON 2-PYRIDINONE AND 2-PYRIDINETHIONE

Some new azo sulfa drugs -[4-(N-substituted)sulfamyl]phenylazo-2-pyrid inone dyes (1-6) and (N-substituted)sulfamyl]phenylazo-2-pyridinethion e dyes (1'-6') were synthesized by coupling of 4-(N-substituted)sulfam ylbenzene diazonium salts with 3-cyano-4,6-diphenyl-2-pyridinone and/o r with 3-cyano-4,6-diphenyl-2-pyridin-ethione. The corresponding iron (1a-6a, 1'a-6'a), copper (1b-6b, 1'b-6'b) and mercury (1c-6c, 1'c-6'c) chelates were also prepared. All synthesized compounds were screened in vitro for antibacterial and antifungal activities.