ASPERGILLUS PROTEASE-CATALYZED ESTERIFICATION AT PH-GREATER-THAN-7

Diverse N-substituted amino acids were converted to their correspondin g esters by crude sucrose-immobilized Aspergillus oryzae protease in o rganic solvents at pH 7.5. The front part of captopril S-(-)-acetylthi o-2-methylpropionic acid and the aspartame precursor Cbz-L-ASP-L-Phe-O H also underwent esterification under such conditions.