DETERMINANTS OF ANGIOTENSIN-II-INDUCED HYPERTROPHY VERSUS HYPERPLASIAIN VASCULAR SMOOTH-MUSCLE

There is clear evidence implicating a role for angiotensin II in contr ol of hypertrophic growth of vascular smooth muscle cells in vivo. How ever, the specific mechanisms whereby angiotensin II influences smooth muscle cell growth have not been defined. The focus of this mini-revi ew is to consider how angiotensin II contributes to control of hypertr ophic vs. hyperplastic growth of vascular smooth muscle in vivo, and i n particular how the differentiated state of the smooth muscle cell ma y influence growth responsiveness to angiotensin II.