2 SISTERS WITH MULTIPLE-SCLEROSIS, LAMELLAR ICHTHYOSIS, BETA-THALASSEMIA MINOR AND A DEFICIENCY OF FACTOR-VIII

Authors
CAPRA R MATTIOLI F KALMAN B MARCIANO N BERENZI A BENETTI A
Citation
R. Capra et al., 2 SISTERS WITH MULTIPLE-SCLEROSIS, LAMELLAR ICHTHYOSIS, BETA-THALASSEMIA MINOR AND A DEFICIENCY OF FACTOR-VIII, Journal of neurology, 240(6), 1993, pp. 336-338
Citations number
26
Categorie Soggetti
Clinical Neurology
Journal title
Journal of neurology → ACNP
ISSN journal
03405354
Volume
240
Issue
6
Year of publication
1993
Pages
336 - 338
Database
ISI
SICI code
0340-5354(1993)240:6<336:2SWMLI>2.0.ZU;2-F
Abstract
Two of four sisters have multiple sclerosis (MS), lamellar ichthyosis, beta thalassaemia minor and a quantitative deficit of factor VIII-von Willebrand complex. The mother and the other sisters have only beta t halassaemia minor. The association of MS and a cluster of genetically determined diseases is rare. Such families could offer a new approach to the investigation of the polygenetic background of MS.