Two patients with a slowly progressive and severe motor apraxia are pr
esented. In one case, there was only apraxia; in the other there was m
oderate memory disturbance and a mild decline of global intellectual a
bility, suggesting a more widespread cognitive dysfunction. In this se
cond case, recognition of the correct use of objects was also severely
impaired, suggesting a disturbance of motor knowledge. In both cases,
apraxia was asymmetrical, and associated with a contralateral atrophy
of the upper parietal cortex, suggesting a differential involvement o
f separate action systems for each hand.