SYNTHETIC IMPLANTS FOR THE REPAIR OF OSTEOCHONDRAL DEFECTS OF THE MEDIAL FEMORAL CONDYLE - A BIOMECHANICAL AND HISTOLOGICAL-EVALUATION IN THE RABBIT KNEE

Polyurethane-coated and uncoated polytetrafluoroethylene (PTFE) (Teflo n(R)) and polyester (Dacron(R)) felts were used for repair of full-thi ckness cartilage defects in the rabbit knee. At 3 months the indentati on characteristics and the histological appearance of the repairs were compared with those of a sham-operation, natural repair, and perioste al grafting. Joint compressive load-displacement and indentation chara cteristics of the cartilage adjacent to the defect were normal for all alternatives. All the repair sites had a higher compliance than had n ormal cartilage-bone, but synthetic grafting had values closer to norm al than periosteal grafting. The adjacent cartilage appeared macroscop ically normal, except with periosteal grafting and coated PTFE implant s where it showed surface irregularities in some cases. With periostea l and uncoated synthetic implants the defects were completely filled, but not in the natural repair sites. Most of the coated implants faile d by separation within the implant. On histological examination, ingro wth of trabecular bone from the base of the defect into the synthetic material was seen in all the specimens. The neocartilage 'score' was e qually low with all the repairs reaching only one-third of the maximum points. All the repairs were associated with synovitis. Further, some of the knees with the synthetic materials repair had debris particles in the synovium. We conclude that none of the biological resurfacing techniques described achieved normal articular cartilage characteristi cs at 3 months, although the compliance of the repair site was closer to normal with synthetic than with periosteal grafting.