THE EFFECTS OF ASPIRIN AND ANTIOXIDANT BUTYLATED HYDROXY ANISOLE ON THE LIVER MICROSOMAL BENZO(A)PYRENE HYDROXYLASE-ACTIVITY IN MICE (MUS-MUSCULUS)

In this study the effects of Aspirin and antioxidant Butylated Hydroxy Anisole (BHA) were studied individually and together on the liver mic rosomal Benzo Ta) Pyrene Hydroxylase (BPH) activity in mice (Mus muscu lus). Aspirin and BHA were given to mice by intraperitoneal injection and after the injection at the 2(nd), 4(th), 8(th), 12(th) and 24(th) hours mice were killed by cervical dislocation, their livers were remo ved, and the microsomal fractions were isolated by differantial centri fugation. These fractions were used for the determination of alteratio n of BPH activities. As a result, it was determined that Aspirin and B HA inhibited the BPH activity. The maximum inhibitions were reached be tween 8th - 12th hours after the injections. The levels of inhibitions obtained by Aspirin injected with BHA were higher than those of subst ances injected individually.