DISTRIBUTION OF 8-HYDROXYFLAVONE GLYCOSIDES AND FLAVONOID AGLYCONES IN SOME SPANISH SIDERITIS SPECIES

The occurrence of the anti-inflammatory flavonoids hypolaetin 8-glucos ide, cirsiliol and siderito-flavone, and other flavonoids has been inv estigated in taxonomically related taxa of the genus Sideritis by HPLC . All the analysed taxa showed very similar flavonoid aglycone pattern s, while they had clear differences in the flavonoid glycoside pattern s. The analyses of flavonoid glycosides allowed the differentiation of five different groups of Sideritis taxa, There is a correlation betwe en the chemical groups and the geographical location of the analysed t axa. In S. mugronensis, S. tragoriganum and S. reverchonii, the flavon oids hypolaetin 8-glucuronide, hypolaetin 4'-methyl ether 8-glucoside and 8-glucuronide have also been identified, this being the first time that these substances are reported in the Labiatae.