G. Dean et M. Elian, MOTOR-NEURON DISEASE AND MULTIPLE-SCLEROSIS MORTALITY IN AUSTRALIA, NEW-ZEALAND AND SOUTH-AFRICA COMPARED WITH ENGLAND AND WALES, Journal of Neurology, Neurosurgery and Psychiatry, 56(6), 1993, pp. 633-637
There has been a marked increase in the reported mortality from motor
neuron disease (MND) but not multiple sclerosis (MS) in England and Wa
les and in a number of other countries. A comparison has been made of
the mortality from MND and from MS for two time periods in Australia,
New Zealand and South Africa. An increase in MND mortality occurred in
Australia and New Zealand between 1968-77 and 1978-87, greater than t
hat which occurred in England and Wales, but there was no increase in
MS mortality. Among the white population of South Africa, the MND mort
ality was half of that in England and Wales, Australia and New Zealand
in both time periods. Both MND and MS mortality is higher in the Engl
ish-speaking than in the Afrikaans-speaking white South African-born.
The marked increase in MND mortality which has now been reported from
many countries, is good evidence that an environmental factor is impor
tant in causing this disease. The large differences in MND mortality i
n different populations may be important clues to the environment fact
ors causing the disease.