PARANEOPLASTIC CEREBELLAR DEGENERATION AND LIMBIC ENCEPHALITIS IN A PATIENT WITH ADENOCARCINOMA OF THE COLON

Authors
TSUKAMOTO T MOCHIZUKI R MOCHIZUKI H NOGUCHI M KAYAMA H HIWATASHI M YAMAMOTO T
Citation
T. Tsukamoto et al., PARANEOPLASTIC CEREBELLAR DEGENERATION AND LIMBIC ENCEPHALITIS IN A PATIENT WITH ADENOCARCINOMA OF THE COLON, Journal of Neurology, Neurosurgery and Psychiatry, 56(6), 1993, pp. 713-716
Citations number
18
Categorie Soggetti
Psychiatry,Neurosciences,"Clinical Neurology
Journal title
Journal of Neurology, Neurosurgery and Psychiatry → ACNP
ISSN journal
00223050
Volume
56
Issue
6
Year of publication
1993
Pages
713 - 716
Database
ISI
SICI code
0022-3050(1993)56:6<713:PCDALE>2.0.ZU;2-2
Abstract
The rare association of two neurological paraneoplastic syndromes, par aneoplastic cerebellar degeneration and limbic encephalitis occurred i n a 55 year old woman with a microscopic adenocarcinoma in a colonic p olyp. Complete removal of the tumour by polypectomy brought about a fa vourable recovery from limbic encephalitis but the cerebellar ataxia r emained. High titres of antineuronal nuclear antibody resembling anti- Hu were demonstrated in serum by immunohistochemistry using rat brain as a substrate. The antibody identified a protein band of 41 kDa on a Western immunoblot.