NOVEL POLYMORPHISM IN THE A4-REGION OF THE AMYLOID PRECURSOR PROTEIN GENE IN A PATIENT WITHOUT ALZHEIMERS-DISEASE

Authors
PEACOCK ML WARREN JT ROSES AD FINK JK
Citation
Ml. Peacock et al., NOVEL POLYMORPHISM IN THE A4-REGION OF THE AMYLOID PRECURSOR PROTEIN GENE IN A PATIENT WITHOUT ALZHEIMERS-DISEASE, Neurology, 43(6), 1993, pp. 1254-1256
Citations number
10
Categorie Soggetti
Clinical Neurology
Journal title
Neurology → ACNP
ISSN journal
00283878
Volume
43
Issue
6
Year of publication
1993
Pages
1254 - 1256
Database
ISI
SICI code
0028-3878(1993)43:6<1254:NPITAO>2.0.ZU;2-G
Abstract
We found a novel polymorphism in the amyloid precursor protein (APP) g ene in a patient with ischemic cerebrovascular disease who had no evid ence of Alzheimer's disease (AD). This polymorphism deletes a Fok I re striction enzyme site and causes the substitution of threonine for ala nine at codon 673. This is adjacent to the site at which APP is though t to undergo cleavage in AD. Analysis of this polymorphism may provide insight into the basis of APP processing.