ANTARELIX (EP-24332) A NOVEL WATER-SOLUBLE LHRH ANTAGONIST

Authors
DEGHENGHI R BOUTIGNON F WUTHRICH P LENAERTS V
Citation
R. Deghenghi et al., ANTARELIX (EP-24332) A NOVEL WATER-SOLUBLE LHRH ANTAGONIST, Biomedicine & pharmacotherapy, 47(2-3), 1993, pp. 107-110
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy","Medicine, Research & Experimental
Journal title
Biomedicine & pharmacotherapy → ACNP
ISSN journal
07533322
Volume
47
Issue
2-3
Year of publication
1993
Pages
107 - 110
Database
ISI
SICI code
0753-3322(1993)47:2-3<107:A(ANWL>2.0.ZU;2-D
Abstract
A novel water soluble LHRH antagonist (EP 24332 - Antarelix) is descri bed. Its activity in vitro and in vivo in several animal models is giv en. Antarelix (Ac-D-Nal, D-Cpa, D-Pal, Ser, Tyr, D-Hci, Leu, Lys-(iPr) , Pro, D-Ala-NH2) in view of its potency, modest histamine - liberatin g activity and high water solubility has been selected for further dev elopment.