THE PREVALENCE AND DISTRIBUTION OF RESTS OF MALASSEZ IN THE MOUSE MOLAR AND THEIR POSSIBLE ROLE IN REPAIR AND MAINTENANCE OF THE PERIODONTAL-LIGAMENT

This study sought to determine the prevalence and distribution of thes e rests under normal conditions and after giving 1-hydroxyethylidene-1 , 1-bisphosphonate (HEBP), a drug that interferes with homeostasis in the periodontal ligament. Normally the rests of Malassez were equally distributed on all root aspects with the exception of the mesial of th e mesial root of the first mandibular molar. With increasing age their number decreased. A similar distribution was seen in the animals trea ted with the bisphosphonate, in which there was a severe reduction in width of the periodontal ligament, at several sites resulting in ankyl osis. After discontinuing HEBP the normal width of the periodontal lig ament space was restored. Repair was characterized by root resorption, elimination of ankylosis, cementum formation and regeneration of liga ment. These processes seemed to have no connection with the prevalence and distribution of rests of Malassez. It is concluded that rests of Malassez are unlikely to play an important part in the homeostasis of periodontal ligament and do not seem to be a prerequisite for its repa ir and maintenance.