INTERACTION OF [(DIEN)PTBR]BR WITH 6-OXOPURINE NUCLEOSIDES

Complexes of the general formulae [(dien)Pt(nucl)]Br2, with nucl=guano sine (guo), inosine (ino), xanthosine (xao) and 9-methyl guanine (9-Me G) were first isolated from the reactions of [(dien)PtBr]Br with the n ucleosides. Further reactions between the [(dien)Pt(nucl)]Br2, [(dien) PtBr]Br and K2PtX4 (X=Cl, Br) complexes produced new ones of formulae [(dien)Pt(nucl-H+)]Br, [{(dien)Pt}2(nucl-H+)](ClO4)3, [(dien)Pt(nucl-H +)PtX3] and [(dien)Pt(nucl)](PtX4) (X=Cl, Br). All complexes were char acterized by elemental analysis, conductivity measurements, IR and H-1 NMR spectra. All the nucleosides are firstly coordinated through thei r N7 atoms. This is followed by an attack of a second Pt(II) atom at N 1, after deprotonation of this site in the dinuclear complexes.