The authors describe two cases of a lesion that closely resembled oste
ochondroma occurring at the posterior aspect of the distal femur in th
e popliteal region. Histopathologic examination after open biopsy reve
aled that the lesions were periosteal chondromas, and they were resect
ed. Osteochondroma, particularly that undergoing malignant transformat
ion, should perhaps be considered in the differential diagnosis of per
iosteal chondroma; the key to distinguishing between these two lesions
is the separation of periosteal chondroma from the medullary portion
of the bone by intervening cortex.