PROBLEMS IN RELEASE OF TISSUE-PLASMINOGEN ACTIVATOR FROM VENOUS WALL AS CAUSE FOR RECURRENT THROMBOSIS

Authors
HACHWUNDERLE V SCHARRER I
Citation
V. Hachwunderle et I. Scharrer, PROBLEMS IN RELEASE OF TISSUE-PLASMINOGEN ACTIVATOR FROM VENOUS WALL AS CAUSE FOR RECURRENT THROMBOSIS, VASA, 1993, pp. 5-10
Citations number
44
Categorie Soggetti
Cardiac & Cardiovascular System
Journal title
VASA → ACNP
ISSN journal
03011526
Year of publication
1993
Supplement
39
Pages
5 - 10
Database
ISI
SICI code
0301-1526(1993):<5:PIROTA>2.0.ZU;2-0
Abstract
The release of tissue-type plasminogen activator (t-PA) after venous o cclusion was tested in 290 patients with venous thrombosis, at earlies t three months after the last thromboembolic episode. In 37 patients ( 12,8%) the t-PA-activity was decreased. In 14 patients (4,8%) the defe ct was confirmed by control. A reduced release of t-PA was found in 4 patients, while 10 out of 14 patients had comparatively higher levels of plasminogen-activator-inhibitor (PAI-I).