ARE THERE PROGNOSTIC PARAMETERS THAT ARE ABLE TO PREDICT THE SUCCESS OF INTRAARTERIAL CHEMOTHERAPY IN NONRESECTABLE LIVER METASTASES OF COLORECTAL-CARCINOMA

When compared with systemic therapy, hepatic arterial chemotherapy sig nificantly increases the response rate for hepatic metastases from col orectal carcinomas. However, only 2 studies showed a significant prolo ngation of survival. In our study on 54 patients tumor related charact eristics and the response to regional chemotherapy were correlated to the success of the treatment. In a linear discriminant analysis the re sponse to regional chemotherapy was the main prognostic factor for the 1-year survival, rate, followed by positive lymph nodes in the Lig. h epatoduodenale. The other pretherapeutic factors such as liver involve ment and CEA rate were of less importance.