R. Nustede et al., GASTRIN-RELEASING PEPTIDE AND CHOLECYSTOKININ IN THE REGULATION OF EXOCRINE PANCREATIC-SECRETION IN DOGS, Digestion, 54(2), 1993, pp. 79-83
Exocrine pancreatic secretion in conscious dogs is significantly stimu
lated bv the intravenous application of small doses of gastrin-releasi
ng peptide (GRP; 30 pmol X kg-1 X h-1). There is no increase of the GR
P concentrations in peripheral blood which is also the case under phys
iological postprandial conditions. There is also no increase in the pe
ripheral cholecystokinin (CCK) concentrations, in contrast to previous
reports. Nevertheless other CCK-related mechanisms may play an import
ant role, since the administration of the highly specific CCK receptor
antagonist MK-329 causes a marked reduction of the GRP-induced exocri
ne panceratic secretion.