Ta. Mcnearney et al., EXPRESSION OF COMPLEMENT RECEPTOR-2 (CR-2) ON HTLV-1-INFECTED LYMPHOCYTES AND TRANSFORMED-CELL LINES, European Journal of Immunology, 23(6), 1993, pp. 1266-1270
The expression of complement receptor 2 (CR2) has been demonstrated in
established HTLV-1-transformed cell lines and in 12 studied de novo i
nfected peripheral blood lymphocytes cultures, using 2 HTLV-1 sources.
The simultaneous detection of CR2 and HTLV-1 antigens in both co-cult
ivated and supernatant-infected peripheral blood lymphocytes suggest t
hat the increased CR2 expression is in tandem with the increasing HTLV
-1 antigen expression. CR2 up-regulation seen during polyclonal activa
tion is presumably in response to a viral protein, although a cellular
factor has not been ruled out. Increasing CR2 expression during early
infection suggests its possible involvement in selection or developme
nt of subsequent transformation events. Variable levels of CR2 in immo
rtalized cell lines argue against its obligate expression of function
in the maintenance of the transformed state. The expression of CR2 in
cellular activation of T cells may be stage restricted. This study als
o expands the cellular distribution for CR2.