IRON-MEDIATED SYNTHESIS OF 4-AMINO-ENOATES OF HIGH ENANTIOMERIC PURITY

The nucleophilic addition of various nitrogen nucleophiles to the high ly enantiomerically enriched a3-allyl)-tetracarbonyliron-(1+)-tetraflu oroborate (2) (ee greater-than-or-equal-to 95%) leads after oxidative removal of the tetracarbonyliron group to 4-amino-enoates (S)-3 of hig h enantiomeric purity (ee = 95-98%). The reaction is highly regio- and stereoselective and proceeds in good yields without isomerization of the double bond.