ALPHA-INTERFERON RAISES SERUM BETA-2-MICROGLOBULIN IN PATIENTS TREATED FOR THROMBOCYTHEMIA

Authors
REMES K TIENHAARA A PELLINIEMI TT
Citation
K. Remes et al., ALPHA-INTERFERON RAISES SERUM BETA-2-MICROGLOBULIN IN PATIENTS TREATED FOR THROMBOCYTHEMIA, British Journal of Haematology, 84(2), 1993, pp. 353-355
Citations number
10
Categorie Soggetti
Hematology
Journal title
British Journal of Haematology → ACNP
ISSN journal
00071048
Volume
84
Issue
2
Year of publication
1993
Pages
353 - 355
Database
ISI
SICI code
0007-1048(1993)84:2<353:ARSBIP>2.0.ZU;2-C
Abstract
Serum beta-2-microglobulin (b2m) levels were studied in 10 patients tr eated with alpha interferon (IFN) for thrombocythaemia associated with chronic myeloproliferative diseases. In eight patients the IFN treatm ent decreased the blood platelet level to < 600 x 10(9)/l. Serum b2m l evels rose significantly and dose-dependently immediately after the on set of treatment, by a median maximal increase of 72% with IFN 3 MU ev ery other day, and 95% with 3 MU daily. The b2m rise caused by IFN abo lishes the value of serum b2m in states where b2m is used as an indica tor of disease activity.