CLONING AND MUTATIONAL ANALYSIS OF SRY

A candidate for the male sex-determining gene has recently been isolat ed. This sex-determining gene (SRY) has been found to be mutated in so me individuals with failed testis development, and, in mouse transgene sis, the SRY murine homologue (Sry) causes female-to-male sex reversal . The cloning of SRY should facilitate the characterisation of other g enes in the testis-determining pathway and provide information on the mechanism of mammalian developmental decisions.