I. Mucsi et al., COMBINED EFFECTS OF FLAVONOIDS AND ACYCLOVIR AGAINST HERPESVIRUSES INCELL-CULTURES, Acta microbiologica Hungarica, 39(2), 1992, pp. 137-147
The combined antiviral effects of some flavonoid compounds and acyclog
uanosine (acyclovir, Zovirax) were studied on the multiplication of he
rpes simplex virus types 1 and 2 in HEp-2 cells and on pseudorabies (A
ujeszky) virus in chick embryo fibroblast cells by the yield reduction
method. The flavonoids quercetin, quercitin (quercetin-3-L-rhamnoside
) and apigenin exhibit antiviral activity against these herpesviruses,
and acyclovir is currently one of the most effective antiherpetic age
nts. In these studies, the simultaneous application of flavonoids with
acyclovir resulted in an enhanced antiviral activity. A mathematical
formula was used to interpret the drug interaction, resulting in FIC (
fractional inhibitory concentration) indices. Meaning a synergic inter
action, all combinations exhibited synergy, FIC values of 0.6-0.8 bein
g commonly observed.