FRENCH IVF REGISTRY FIVNAT - 1992 REPORT

FIVNAT registry collected information on 21,960 individual assisted re productive technology (ART) cycles in 1992. The present analysis conce rns 15,557 cycles arrived on time to be incorporated, 97.9 % being in vitro fertilization (IVF) cycles. The transfer rate was 80.9 % and the clinical pregnancy rate was 19.2 % per oocyte recovery cycle and 23.7 % per transfer. The mean oocyte number slightly increased compared to 1991 (8.5 +/- 5.6 vs 8.2 +/- 5.6, p < 0.001) whereas the mean number of embryos obtained was not modified and the mean number of transferre d oocytes slightly decreased. The mean fertilization rate slightly inc reased (53.0 % +/- 30.2 % vs 48.3 % +/- 32.7%, p < 0.001). Infertility of tubal origin represented 59.1 % of infertilities and cycles realis ed with donor semen were associated to the highest pregnancy rate. GnR H analogues were widely used (87.5 %), but those using a short blockin g period tended to decrease, replaced by protocols without GnRH analog ues. Stimulation regimen using a long blockage phase were associated t o a higher pregnancy rate than the others (19.8 % per recovery). The p roportion of transfers involving 4 or more embryos decreased in 1991 t o 22.9 %. The analysis of 7 960 pregnancy forms resulting of recoverie s realised from 1987 to 1991 showed a preterm birth rate of 9.2 % for singleton, but a still high rate for twins and multiple pregnancies. F or singleton pregnancies, in utero mortality concerned 6.9 parts per t housand of the children, and the neonatal mortality rate (< 7 days) wa s 6.7 parts per thousand. The overall malformation rate was 2.8 %.