LAMIN-A C GENE AND A RELATED SEQUENCE MAP TO HUMAN CHROMOSOME-1Q12.1-Q23 AND CHROMOSOME-10/

Authors
KAMAT AK ROCCHI M SMITH DI MILLER OJ
Citation
Ak. Kamat et al., LAMIN-A C GENE AND A RELATED SEQUENCE MAP TO HUMAN CHROMOSOME-1Q12.1-Q23 AND CHROMOSOME-10/, Somatic cell and molecular genetics, 19(2), 1993, pp. 203-208
Citations number
13
Categorie Soggetti
Cytology & Histology","Genetics & Heredity",Biology
Journal title
Somatic cell and molecular genetics → ACNP
ISSN journal
07407750
Volume
19
Issue
2
Year of publication
1993
Pages
203 - 208
Database
ISI
SICI code
0740-7750(1993)19:2<203:LCGAAR>2.0.ZU;2-Y
Abstract
Lamins A and C are products of alternate splicing of one transcript fr om a single gene. We have isolated a partial cDNA, cE1-2, whose 800-bp sequence is 99% identical to the 3' untranslated region of the lamin A/C gene. We report here the mapping of this gene and a closely relate d sequence to human chromosomes 1 and 10, more specifically, to 1q12.1 -q23. The localization of cE1-2 hybridizing sequences to two different chromosomes suggests that one of these loci represents an as yet unkn own member of the lamin gene family, either a pseudogene or an express ed gene.