NONANTIGEN SIGNALS FOR B-CELL GROWTH AND DIFFERENTIATION TO ANTIBODY SECRETION

Authors
LEDERMAN S YELLIN MJ COVEY LR CLEARY AM CALLARD R CHESS L
Citation
S. Lederman et al., NONANTIGEN SIGNALS FOR B-CELL GROWTH AND DIFFERENTIATION TO ANTIBODY SECRETION, Current opinion in immunology, 5(3), 1993, pp. 439-444
Citations number
39
Categorie Soggetti
Immunology
Journal title
Current opinion in immunology → ACNP
ISSN journal
09527915
Volume
5
Issue
3
Year of publication
1993
Pages
439 - 444
Database
ISI
SICI code
0952-7915(1993)5:3<439:NSFBGA>2.0.ZU;2-E
Abstract
Recently, significant progress had been made in understanding the T-B lymphocyte interactions that control humoral immunity. This review hig hlights experiments that demonstrate a central role for interactions b etween T-cell-B-cell-activating molecule (CD40 ligand) expressed on T cells and CD40 on B cells in B-cell activation and immunoglobulin isot ype switching, both in vitro and in vivo.