Four groups of lambs aged 1 week, -4 weeks, 1/2 year and 1 year old re
spectively were inoculated with Ehrlichia phagocytophila infected bloo
d. Clinical signs, temperature reactions, haematological changes and p
arasitaemia were more moderate in lambs inoculated with E. phagocytoph
ila at the age of 1 week than those recorded in the older animals. The
clinical response to tick-borne fever (TBF) appears to be more severe
with increasing age of the lambs. The lymphocyte reactivity to mitoge
ns was reduced in the TBF infected lambs, and was most pronounced in l
ambs in the 3 older age groups.