A RANDOMIZED TRIAL ABOUT THE PERCEIVED INFORMATIVENESS OF NEW EMPIRICAL-EVIDENCE - DOES BETA-CAROTENE PREVENT (CERVICAL) CANCER

The perceived informativeness of a publication can be assessed by meas uring the change in belief it induces among the scientific public, reg arding a certain hypothesis. In a randomized trial. we studied the eff ect of empirical evidence from a clinical experiment and a case contro l study on the hypothesis that beta-carotene protects against (cervica l) cancer. The study population consisted of first authors of recently published patient-oriented research papers. They received an abstract of the clinical experiment, of the case-control study, or a ''placebo '' abstract. The latter was used to assess the specific effect of the empirical evidence in the two real studies. The change in belief in th e hypotheses was expressed as a likelihood ratio (LR). All three abstr acts led to a decrease in belief in the hypothesis. The median LRs of the abstracts of the experiment, case-control study and ''placebo'' we re 0.33, 0.45, 0.75 respectively. This paper shows that the belief in a certain hypothesis is influenced by the quality of empirical evidenc e in a study. The magnitude of change induced by the experimental and case-control abstract had the anticipated order, but the change in bel ief induced by the ''placebo'' abstract was larger than we had expecte d. Reasons for this may be the concise information in the abstract and the variable methodological training of the study population.