7-DAY VARIABLE-STRESS REGIME ALTERS CORTICAL BETA-ADRENOCEPTOR BINDING AND IMMUNOLOGICAL RESPONSES - REVERSAL BY IMIPRAMINE

Citation
Am. Basso et al., 7-DAY VARIABLE-STRESS REGIME ALTERS CORTICAL BETA-ADRENOCEPTOR BINDING AND IMMUNOLOGICAL RESPONSES - REVERSAL BY IMIPRAMINE, Pharmacology, biochemistry and behavior, 45(3), 1993, pp. 665-672
Citations number
44
Categorie Soggetti
Pharmacology & Pharmacy
ISSN journal
00913057
Volume
45
Issue
3
Year of publication
1993
Pages
665 - 672
Database
ISI
SICI code
0091-3057(1993)45:3<665:7VRACB>2.0.ZU;2-L
Abstract
Rats were submitted daily to a variable stressor for 1 week with or wi thout concurrent imipramine (IMI) administration. One day after the la st injection or stressful event, binding of cortical beta-adrenoceptor s was determined in all experimental groups. Another group of chronica lly stressed animals with or without concurrent IMI administration wer e sacrificed 24 h following the last stress or injection treatment, an d several immunologic parameters were evaluated. Chronically stressed rats showed an enhanced number of cortical beta-adrenergic sites witho ut changes in their affinity. This effect was not present following co ncurrent administration with the antidepressant. In addition, a decrea sed percentage of T lymphocytes and a reduced delayed-type hypersensit ivity reaction was also observed in stressed animals. Both responses w ere no longer evident when stressed rats were previously administered IMI. A possible link between behavioral, neurochemical, and immunologi c alterations due to the stress regime is discussed.