Sr. Babu et al., EFFECT OF PHYSOSTIGMINE AND EXERCISE ON CHOLINE-ACETYLTRANSFERASE ANDACETYLCHOLINESTERASE ACTIVITIES IN FAST AND SLOW MUSCLES OF RAT, Pharmacology, biochemistry and behavior, 45(3), 1993, pp. 713-717
The interaction of physostigmine (Phy) and exercise on cholineacetyltr
ansferase (ChAT) and acetylcholinesterase (AChE) have been studied in
the fast extensor digitorum longus (EDL) and slow soleus muscles of ra
t. ChAT decreased significantly by trained exercise in EDL muscle and
Phy prolonged this effect even up to 24 h. Soleus muscles showed a sma
ll increase of ChAT due to exercise but Phy + exercise did not change
significantly. Both EDL and soleus showed a marked decrease in AChE ac
tivity due to subacute administration of Phy + trained exercise, exhib
iting an additive effect. No recovery was observed in ChAT and AChE ac
tivities of EDL even after 24 h in Phy + trained exercise group. Our r
esults suggest that Phy and exercise has significant effect on the syn
thetic (ChAT) and degradative (AChE) enzymes of acetylcholine in activ
e EDL muscle. Exercise has prolonged the inhibitory effect of Phy on C
hAT and AChE activities both in active EDL and passive soleus muscles.
This study showed that Phy + exercise modified the functional activit
y of cholinergic system in EDL and soleus muscles.