CARBACHOL AND NALOXONE SYNERGISTICALLY ELEVATE DOPAMINE RELEASE IN RAT STRIATUM - AN INVIVO MICRODIALYSIS STUDY

Authors
KISCHKA U FARBER SA MARSHALL D WURTMAN RJ
Citation
U. Kischka et al., CARBACHOL AND NALOXONE SYNERGISTICALLY ELEVATE DOPAMINE RELEASE IN RAT STRIATUM - AN INVIVO MICRODIALYSIS STUDY, Brain research, 613(2), 1993, pp. 288-290
Citations number
27
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
613
Issue
2
Year of publication
1993
Pages
288 - 290
Database
ISI
SICI code
0006-8993(1993)613:2<288:CANSED>2.0.ZU;2-C
Abstract
Striatal dopamine (DA) release increased to 184% of baseline after 10- 20 min of continuous intrastriatal perfusion with 10 mM carbachol, dro pping to 124% after 30-40 min. The addition of 100 muM naloxone amplif ied (to 236% of baseline) and prolonged the increase in DA release, bu t naloxone alone (up to 1 mM) had no effect. These data suggest that a ctivation of opiate-releasing striatal neurons suppresses cholinergic stimulation of DA release.