ADENOSINE RECEPTOR ANTAGONISTS POTENTIATE DOPAMINE RECEPTOR AGONIST-INDUCED ROTATIONAL BEHAVIOR IN 6-HYDROXYDOPAMINE-LESIONED RATS

Authors
JIANG H JACKSONLEWIS V MUTHANE U DOLLISON A FERREIRA M ESPINOSA A PARSONS B PRZEDBORSKI S
Citation
H. Jiang et al., ADENOSINE RECEPTOR ANTAGONISTS POTENTIATE DOPAMINE RECEPTOR AGONIST-INDUCED ROTATIONAL BEHAVIOR IN 6-HYDROXYDOPAMINE-LESIONED RATS, Brain research, 613(2), 1993, pp. 347-351
Citations number
27
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
613
Issue
2
Year of publication
1993
Pages
347 - 351
Database
ISI
SICI code
0006-8993(1993)613:2<347:ARAPDR>2.0.ZU;2-U
Abstract
Adenosine receptor antagonists, DMPX, PACPX and theophylline, produce contralateral rotations in unilateral 6-hydroxydopamine-lesioned rats. DMPX and theophylline markedly increase rotations produced by bromocr iptine (a dopamine D2 receptor agonist) and/or SKF38393A (a dopamine D 1 receptor agonist). All of these effects are inhibited by CGS21680C ( an adenosine A2 receptor agonist). These findings suggest synergistic interactions among D1, D2 and A2 receptors that may be relevant to the treatment of Parkinson's disease.