ISOLATION AND IDENTIFICATION OF IMPURITIES IN L-696,229 DRUG SUBSTANCE

Authors
PRABHU SV BALLARD JM REAMER RA ELLISON DK
Citation
Sv. Prabhu et al., ISOLATION AND IDENTIFICATION OF IMPURITIES IN L-696,229 DRUG SUBSTANCE, Talanta, 40(7), 1993, pp. 989-994
Citations number
7
Journal title
Talanta
ISSN journal
00399140 → ACNP
Volume
40
Issue
7
Year of publication
1993
Pages
989 - 994
Database
ISI
SICI code
0039-9140(1993)40:7<989:IAIOII>2.0.ZU;2-B
Abstract
Two low level impurities in zoxazolyl)ethyl]-5-ethyl-6-methyl-2(1H)-py ridinone drug substance (L-696,229) have been isolated by a combinatio n of preparative HPLC, solid-phase extraction and liquid-liquid extrac tion. They were identified as )ethyl]-5-ethyl-6-(2-phenylethyl)-2(1H)- pyridinone (I) and 2-(2-benzoxazolyl)ethyl]-5-ethyl-2(1H)-pyridinone] (II) by mass spectrometry and by their C-13 and H-1-NMR spectra.