THE SYNTHESIS OF HETEROSUBSTITUTED BENZIMIDAZOLE DERIVATIVES WITH POTENT ANGIOTENSIN-II ANTAGONIST ACTIVITY

Authors
GIBSON KH WOOD R OLDHAM AA MAJOR JS
Citation
Kh. Gibson et al., THE SYNTHESIS OF HETEROSUBSTITUTED BENZIMIDAZOLE DERIVATIVES WITH POTENT ANGIOTENSIN-II ANTAGONIST ACTIVITY, Bioorganic & medicinal chemistry letters, 3(6), 1993, pp. 1019-1024
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
6
Year of publication
1993
Pages
1019 - 1024
Database
ISI
SICI code
0960-894X(1993)3:6<1019:TSOHBD>2.0.ZU;2-V
Abstract
The syntheses and biological activities of novel imidazo[4,5-d]pyridaz ine and imidazo[4,5-c] pyridone derivatives are reported. These series include analogues which have in vitro and in vivo Angiotensin II anta gonist activities which are amongst the most potent yet recorded.