STABLE ISOSTERES OF NEUROTENSIN C-TERMINAL PENTAPEPTIDES DERIVED BY MODIFICATION OF THE AMIDE FUNCTION

Authors
CHRISTOS TE ARVANITIS A CAIN GA JOHNSON AL POTTORF RS TAM SW SCHMIDT WK
Citation
Te. Christos et al., STABLE ISOSTERES OF NEUROTENSIN C-TERMINAL PENTAPEPTIDES DERIVED BY MODIFICATION OF THE AMIDE FUNCTION, Bioorganic & medicinal chemistry letters, 3(6), 1993, pp. 1035-1040
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
6
Year of publication
1993
Pages
1035 - 1040
Database
ISI
SICI code
0960-894X(1993)3:6<1035:SIONCP>2.0.ZU;2-5
Abstract
A series of amide bond modified neurotensin c-terminal pentapeptides h as been prepared and tested for their in vivo analgesic properties. Re duced amide function and trans double bond isosteres did show analgesi c activity.