PENTAMIDINE CONGENERS .1. SYNTHESIS OF CIS-BUTAMIDINE AND TRANS-BUTAMIDINE ANALOGS AS ANTI-PNEUMOCYSTIS-CARINII PNEUMONIA AGENTS

Authors
DONKOR IO JONES SK TIDWELL RR
Citation
Io. Donkor et al., PENTAMIDINE CONGENERS .1. SYNTHESIS OF CIS-BUTAMIDINE AND TRANS-BUTAMIDINE ANALOGS AS ANTI-PNEUMOCYSTIS-CARINII PNEUMONIA AGENTS, Bioorganic & medicinal chemistry letters, 3(6), 1993, pp. 1137-1140
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
6
Year of publication
1993
Pages
1137 - 1140
Database
ISI
SICI code
0960-894X(1993)3:6<1137:PC.SOC>2.0.ZU;2-N
Abstract
Butamidine analogues possessing unsaturation in the ether bridge betwe en the bisamidinophenyl or bisimidazolinophenyl functionalities have b een synthesized as semirigid congeners of pentamidine. These compounds demonstrated good anti-P. carinii pneumonia activity in a rat model o f the disease.