ACID UNIT MODIFICATIONS OF 1,2,4,5-SUBSTITUTED HYDROXYACETOPHENONES AND THE EFFECT ON INVITRO AND INVIVO LTB(4) RECEPTOR ANTAGONISM

Authors
SOFIA MJ FLOREANCIG P JACKSON WT MARDER P SAUSSY DL SILBAUGH SA COCKERHAM SL FROELICH LL ROMAN CR STENGEL PW FLEISCH JH
Citation
Mj. Sofia et al., ACID UNIT MODIFICATIONS OF 1,2,4,5-SUBSTITUTED HYDROXYACETOPHENONES AND THE EFFECT ON INVITRO AND INVIVO LTB(4) RECEPTOR ANTAGONISM, Bioorganic & medicinal chemistry letters, 3(6), 1993, pp. 1147-1152
Citations number
34
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
6
Year of publication
1993
Pages
1147 - 1152
Database
ISI
SICI code
0960-894X(1993)3:6<1147:AUMO1H>2.0.ZU;2-F
Abstract
-3,4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylic acid sodium salt 7 (LY247826) and several 2-ethyl-5-hydroxyphenoxy)propoxy)-2-propylpheno xy] acetic acid analogues were prepared as LTB4 receptor antagonists. When compared with LY255283 and SC-41930, these antagonists showed imp roved in vitro LTB4 receptor antagonism and/or in vivo activity.