QSAR STUDY OF BENZOQUINOLINONES AS INHIBITORS OF HUMAN TYPE-1 5-ALPHA-REDUCTASE

Authors
WIKEL JH BEMIS KG AUDIA JE MCQUIAD LA JONES CD PENNINGTON PA LAWHORN DE HIRSCH KR STAMM NB
Citation
Jh. Wikel et al., QSAR STUDY OF BENZOQUINOLINONES AS INHIBITORS OF HUMAN TYPE-1 5-ALPHA-REDUCTASE, Bioorganic & medicinal chemistry letters, 3(6), 1993, pp. 1157-1162
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
6
Year of publication
1993
Pages
1157 - 1162
Database
ISI
SICI code
0960-894X(1993)3:6<1157:QSOBAI>2.0.ZU;2-R
Abstract
QSAR models have been developed with regression analysis that related a specific lipophilic feature of the substituent of the molecule with biological activity. A second important feature of the compounds, the energy of the HOMO, was revealed using a simple visualization techniqu e.