DIRECTED EVOLUTION OF NOVEL BIOSYNTHETIC PATHWAYS - GROWTH OF AN ESCHERICHIA-COLI PROLINE AUXOTROPH ON DELTA(1)-PYRROLINE-2-CARBOXYLIC ACID

Authors
SUTHERLAND JD WILSON EJ WRIGHT MC
Citation
Jd. Sutherland et al., DIRECTED EVOLUTION OF NOVEL BIOSYNTHETIC PATHWAYS - GROWTH OF AN ESCHERICHIA-COLI PROLINE AUXOTROPH ON DELTA(1)-PYRROLINE-2-CARBOXYLIC ACID, Bioorganic & medicinal chemistry letters, 3(6), 1993, pp. 1185-1188
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
6
Year of publication
1993
Pages
1185 - 1188
Database
ISI
SICI code
0960-894X(1993)3:6<1185:DEONBP>2.0.ZU;2-H
Abstract
A directed approach to the evolution of novel biosynthetic pathways is exemplified by the selection of plasmids which enhance the growth of an Escherichia coli proline auxotroph on an unnatural precursor, DELTA 1-pyrroline-2-carboxylic acid 2.