DIFFERENCES IN ANTIVIRAL ACTIVITIES FOR ISOMERS OF A FLUORINATED CYCLOBUTANE NUCLEOSIDE ANALOG

Authors
VITE GD TINO JA ZAHLER R GOODFELLOW V TUOMARI AV MCGEEVERRUBIN B FIELD AK
Citation
Gd. Vite et al., DIFFERENCES IN ANTIVIRAL ACTIVITIES FOR ISOMERS OF A FLUORINATED CYCLOBUTANE NUCLEOSIDE ANALOG, Bioorganic & medicinal chemistry letters, 3(6), 1993, pp. 1211-1214
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
6
Year of publication
1993
Pages
1211 - 1214
Database
ISI
SICI code
0960-894X(1993)3:6<1211:DIAAFI>2.0.ZU;2-P
Abstract
Isomeric fluorinated cyclobutane nucleoside analogs (+/-)-2 and (+/-)- 3 were prepared via multi-step syntheses. Compound 2 is a potent inhib itor of herpes viruses in cell culture assays, while the configuration al isomer 3 is devoid of antiviral activity.