DOUBLE-HEADED MOLECULES BASED ON LINEAR OR ANGULAR PSORALEN AND ALPHA-METHYLENE-GAMMA-BUTYROLACTONE - A SEARCH FOR NON-PHOTOTOXIC POTENTIALANTIPROLIFERATIVE COMPOUNDS

Authors
BUSSEY C LEPOITTEVIN JP BENEZRA C
Citation
C. Bussey et al., DOUBLE-HEADED MOLECULES BASED ON LINEAR OR ANGULAR PSORALEN AND ALPHA-METHYLENE-GAMMA-BUTYROLACTONE - A SEARCH FOR NON-PHOTOTOXIC POTENTIALANTIPROLIFERATIVE COMPOUNDS, Bioorganic & medicinal chemistry letters, 3(6), 1993, pp. 1283-1286
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
6
Year of publication
1993
Pages
1283 - 1286
Database
ISI
SICI code
0960-894X(1993)3:6<1283:DMBOLO>2.0.ZU;2-Y
Abstract
Two double-headed molecules have been synthesised by linking a photore active linear 1 or angular 2 psoralen via a straight ten-carbons chain to an electrophilic alpha-methylene-gamma-butyrolactone. Their photot oxicity was then evaluated by the mouse ear-swelling test and compared with that of the reference compounds 5-methoxypsoralen and angelicin. Compounds 1 and 2 were found to be non-phototoxic at concentrations 1 20 fold higher than the minimal phototoxic dose of 5-MOP.