TRISNORSQUALENE METHYL HYDROXYLAMINE - A POTENT DUAL INHIBITOR OF MAMMALIAN SQUALENE EPOXIDASE AND OXIDOSQUALENE CYCLASE

Authors
ANSTEAD GM LIN HK PRESTWICH GD
Citation
Gm. Anstead et al., TRISNORSQUALENE METHYL HYDROXYLAMINE - A POTENT DUAL INHIBITOR OF MAMMALIAN SQUALENE EPOXIDASE AND OXIDOSQUALENE CYCLASE, Bioorganic & medicinal chemistry letters, 3(6), 1993, pp. 1319-1322
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
6
Year of publication
1993
Pages
1319 - 1322
Database
ISI
SICI code
0960-894X(1993)3:6<1319:TMH-AP>2.0.ZU;2-Z
Abstract
Squalene epoxidase and oxidosqualene cyclase, two sequential enzymes i n the sterol biosynthesis pathway, are inhibited effectively by trisno rsqualene methyl hydroxylamine.