A REINVESTIGATION OF THE TAXOL CONTENT OF HIMALAYAN TAXUS-WALLICHIANAZUCC AND A REVISION OF THE STRUCTURE OF BREVIFOLIOL

Authors
GEORG GI GOLLAPUDI SR GRUNEWALD GL GUNN CW HIMES RH RAO BK LIANG XZ MIRHOM YW MITSCHER LA VANDERVELDE DG YE QM
Citation
Gi. Georg et al., A REINVESTIGATION OF THE TAXOL CONTENT OF HIMALAYAN TAXUS-WALLICHIANAZUCC AND A REVISION OF THE STRUCTURE OF BREVIFOLIOL, Bioorganic & medicinal chemistry letters, 3(6), 1993, pp. 1345-1348
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
6
Year of publication
1993
Pages
1345 - 1348
Database
ISI
SICI code
0960-894X(1993)3:6<1345:AROTTC>2.0.ZU;2-V
Abstract
When taken at the appropriate time and place, biorenewable leaves of t he abundant Himalayan yew, Taxus wallichiana Zucc., contain significan t quantities (0.045-0.130%) of taxol and other useful taxanes includin g 10-deacetylbaccatin III and brevifoliol. Spectroscopic reexamination of brevifoliol indicates that its structure must be revised to 11. Th is makes brevifoliol and recently reported taxchinin A (12) close mole cular relatives.