PROTEIN DAMAGE CAUSED BY A SYNTHETIC ENEDIYNE CORE

Authors
ZEIN N SOLOMON W CASAZZA AM KADOW JF KRISHNAN BS TUN MM VYAS DM DOYLE TW
Citation
N. Zein et al., PROTEIN DAMAGE CAUSED BY A SYNTHETIC ENEDIYNE CORE, Bioorganic & medicinal chemistry letters, 3(6), 1993, pp. 1351-1356
Citations number
35
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
6
Year of publication
1993
Pages
1351 - 1356
Database
ISI
SICI code
0960-894X(1993)3:6<1351:PDCBAS>2.0.ZU;2-M
Abstract
The simple enediyne core molecule 1 is shown to cause protein damage t o several cellular protein isolates in vitro. The aromatization of 1 t o generate a benzene diradical under simulated physiological condition s is also described.