QUINUCLIDINE-BASED NK-1 ANTAGONISTS .1. 3-BENZYLOXY-1-AZABICYCLO[2.2.2]OCTANES

Authors
SEWARD EM SWAIN CJ MERCHANT KJ OWEN SN SABIN V CASCIERI MA SADOWSKI S STRADER C BAKER R
Citation
Em. Seward et al., QUINUCLIDINE-BASED NK-1 ANTAGONISTS .1. 3-BENZYLOXY-1-AZABICYCLO[2.2.2]OCTANES, Bioorganic & medicinal chemistry letters, 3(6), 1993, pp. 1361-1366
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
6
Year of publication
1993
Pages
1361 - 1366
Database
ISI
SICI code
0960-894X(1993)3:6<1361:QNA.3>2.0.ZU;2-O
Abstract
A series of 3-benzyloxy-derivatives of CP-96,345 has been evaluated an d found to have significant affinity for the human NK1 receptor. 3,5-D isubstitution of the benzyl ether has been identified to be essential for high affinity.