Rd. Clark et al., N-(QUINUCLIDIN-3-YL)-1,8-NAPHTHALIMIDES WITH 5-HT(3) RECEPTOR ANTAGONIST AND 5-HT(4) RECEPTOR AGONIST PROPERTIES, Bioorganic & medicinal chemistry letters, 3(6), 1993, pp. 1375-1378
The enantiomers of inuclidin-3-yl)-4-amino-3-chloro-1,8-naphthalimide
(3) were examined for interactions at 5-HT3 and 5-HT4 receptors. (R)-3
was found to be a potent 5-HT3 receptor antagonist while (S)-3 was fo
und to be a 5-HT4 receptor agonist with reduced 5-HT3 receptor affinit
y.