INVESTIGATION OF SIDE-CHAIN SAR, FORMULATION AND INJECTION SITE TOLERATION OF PYRAZOLO[3,4-F]QUINOLINE DERIVATIVES - A POTENT SERIES OF INVIVO ACTIVE IMMUNOSTIMULANTS

Authors
MOYER MP WEBER FH CANNING PC GROSS JL SAINTFORT R
Citation
Mp. Moyer et al., INVESTIGATION OF SIDE-CHAIN SAR, FORMULATION AND INJECTION SITE TOLERATION OF PYRAZOLO[3,4-F]QUINOLINE DERIVATIVES - A POTENT SERIES OF INVIVO ACTIVE IMMUNOSTIMULANTS, Bioorganic & medicinal chemistry letters, 3(6), 1993, pp. 1379-1384
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
6
Year of publication
1993
Pages
1379 - 1384
Database
ISI
SICI code
0960-894X(1993)3:6<1379:IOSSFA>2.0.ZU;2-1
Abstract
Pyrazolo[3,4-f]quinoline derivatives represent a novel class of immuno stimulant with potent in vivo effects in a murine infection model. Sid e-chain SAR, formulation issues and injection site toleration studies have been addressed and compounds suitable for extensive in vivo evalu ation have been identified. The results of these investigations are pr esented in this report.