THIOPHENE SYSTEMS .15. SYNTHESIS AND ANTIHYPERTENSIVE ACTIVITY OF 7-(SUBSTITUTED BENZAMIDO)-6-HYDROXYTHIENO[3,2-B]PYRANS AS NEW POTASSIUM CHANNEL ACTIVATORS

Authors
SANFILIPPO PJ MCNALLY JJ PRESS JB FALOTICO R GIARDINO E KATZ LB
Citation
Pj. Sanfilippo et al., THIOPHENE SYSTEMS .15. SYNTHESIS AND ANTIHYPERTENSIVE ACTIVITY OF 7-(SUBSTITUTED BENZAMIDO)-6-HYDROXYTHIENO[3,2-B]PYRANS AS NEW POTASSIUM CHANNEL ACTIVATORS, Bioorganic & medicinal chemistry letters, 3(6), 1993, pp. 1385-1388
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
6
Year of publication
1993
Pages
1385 - 1388
Database
ISI
SICI code
0960-894X(1993)3:6<1385:TS.SAA>2.0.ZU;2-D
Abstract
The synthesis and antihypertensive activity of novel 7-(substituted nz amido)-6-hydroxy-5,5-dimethylthieno[3,2-b]pyrans are described. Acetyl substitution on the thiophene significantly increases potency of thes e benzamides in contrast to the nitro substitution which gives the bes t results in the 7-(cyclic amido)-6-hydroxythieno[3,2-b]pyran series. Compound 21 is 3-fold more potent than the benzopyran cromakalim (2).