AN INTERACTION OF BETA-AMYLOID WITH ALUMINUM INVITRO

Authors
EXLEY C PRICE NC KELLY SM BIRCHALL JD
Citation
C. Exley et al., AN INTERACTION OF BETA-AMYLOID WITH ALUMINUM INVITRO, FEBS letters, 324(3), 1993, pp. 293-295
Citations number
12
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
324
Issue
3
Year of publication
1993
Pages
293 - 295
Database
ISI
SICI code
0014-5793(1993)324:3<293:AIOBWA>2.0.ZU;2-2
Abstract
We have used circular dichroism spectroscopy to confirm that, in a mem brane-mimicking solvent, AbetaP(1-40) adopts a partially helical confo rmation and we have demonstrated the loss of this structure in the pre sence of physiologically relevant concentrations of aluminium. This is the first evidence of a direct biochemical interaction between alumin ium and beta-amyloid and may have important implications for the patho genesis of Alzheimer's disease.