EFFICIENT DESULFURIZATION OF 2-THIOPYRIMIDINE NUCLEOSIDES TO THE CORRESPONDING 4-PYRIMIDINONES

Authors
KUIMELIS RG NAMBIAR KP
Citation
Rg. Kuimelis et Kp. Nambiar, EFFICIENT DESULFURIZATION OF 2-THIOPYRIMIDINE NUCLEOSIDES TO THE CORRESPONDING 4-PYRIMIDINONES, Tetrahedron letters, 34(24), 1993, pp. 3813-3816
Citations number
28
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
24
Year of publication
1993
Pages
3813 - 3816
Database
ISI
SICI code
0040-4039(1993)34:24<3813:EDO2NT>2.0.ZU;2-#
Abstract
A procedure is described for the preparation of 2'-deoxy-4-pyrimidinon e (dH2U) and 2'-deoxy-5-methyl-4-pyrimidinone (dH2T) nucleosides. The key transformation is a nearly quantitative desulfurization of the cor responding 2-thio analogue by a brief treatment with a m-chloroperbenz oic acid/pyridine solution. The phosphoramidites of these nucleosides have also been synthesized.